Name the defective integrin associated with junctional epidermolysis bullosa (JEB) in Charolais calves

1. List two (2) keratins that are expressed in hyperproliferative keratinocytes. (1 mark)
2. Name the defective integrin associated with junctional epidermolysis bullosa (JEB) in
Charolais calves. (1 mark)
3. List two (2) glycoprotein cell surface receptors (integrins) expressed in the epidermis.
(1 mark)
4. Name two (2) functions of canine Merkel cells. (1 mark)
5. List two (2) key functions of epidermal Langerhans cells. (1 mark)
6. Name the mineral that determines the hardness of the claw in German shepherd dogs.
(1 mark)
7. Name the glycosaminoglycan responsible for the phenotypic appearance of the
Chinese Shar pei dog. (1 mark)
8. Name a resident dermal cell that contains abundant vimentin. (1 mark)
9. Name one (1) CD marker that is positive in dermal dendritic cells and negative in
Langerhans cells. (1 mark)
Section A continued over page
Veterinary Dermatology Paper 1 Page 3 of 8
© 2016 The Australian and New Zealand College of Veterinary Scientists ABN 00 50 000894 208
10. Name two (2) cutaneous cells dependent on stem cell factor for embryologic
development. (1 mark)
11. Name the term used to define hairless telogen. (1 mark)
12. Name two (2) fatty acids that are components of sebum. (1 mark)
13. Name the location of merocrine sweat glands in ungulates. (1 mark)
14. Name one (1) histochemical marker of neoplastic epidermal proliferation. (1 mark)
15. List two (2) major growth factors involved in epidermal wound healing. (1 mark)
16. Name two (2) enzymes released from canine mast cells after IgE mediated activation.
(1 mark)
17. Name two (2) key cytokines that initiate a pro-inflammatory response in the innate
immune system. (1 mark)
18. Name the keratinocyte surface receptor that recognises chitin in the exoskeleton of
Demodex canis. (1 mark)
19. Name the receptor on a cytotoxic T cell that interacts with the major
histocompatibility complex (MHC) class I receptor. (1 mark)
20. Name the ligand and receptor required for T helper 2 (Th2) lymphocyte activation by
dermal dendritic cells in association with the MHC class II molecule. (1 mark)
Section A continued over page
Veterinary Dermatology Paper 1 Page 4 of 8
© 2016 The Australian and New Zealand College of Veterinary Scientists ABN 00 50 000894 208
21. Name the equine skin condition in which the cytokine thymic stromal lymphopoeitin
(TSLP) is overexpressed. (1 mark)
22. Name the molecular structure that is the target of autoantibodies in human
autoimmune urticaria. (1 mark)
23. Name the antibody isotype that has a dimeric structure. (1 mark)
24. Name the genetic disease in which mutations of two (2) separate genes (LAMC2 and
LAMA3) cause an identical phenotype in the horse. (1 mark)
25. Name the iron binding protein that inhibits the growth of Malassezia pachydermatis
in vitro. (1 mark)
26. Define the term ‘koilocyte’. (1 mark)
27. List two (2) mechanisms by which glucocorticoids alter thyroid hormone physiology
to induce euthyroid sick syndrome. (1 mark)
28. Name the organ where conversion of thyroxine (T4) to triiodothyronine (T3) occurs.
(1 mark)
29. Name the step in the cholesterol to cortisol pathway catalysed by 3 betahydroxysteroid
dehydrogenase. (1 mark)
30. Name the precursor of adrenocorticotropic hormone (ACTH) and melanocyte
stimulating hormone (MSH). (1 mark)


 

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